Patani debuted with a Telugu film, Loafer alongside Varun Tej in 2015.[13] She played the role of Mouni, a girl who runs from home to escape a forced marriage.[

Disha appeared in a music video, Befikra along with Tiger Shroff which was produced by Bhushan Kumar and Krishan Kumar under T-Series and composed by Meet Bros.

Patani found her commercial break with Neeraj Pandey's M.S. Dhoni: The Untold Story, a biographical sports film based on the life story of Mahendra Singh Dhon

She played the role of Priyanka Jha, the girlfriend of Mahendra Singh Dhoni's character who dies in a car accident.

Renuka Vyavahare of Times of India reviewed, "the performance of Disha in the film deserves a special mention as her performance tugs at your heartstrings."

Patani then acted in Baaghi 2 along with Tiger Shroff, a sequel to the 2016 hit Baaghi starring Tiger Shroff and Shraddha Kapoor.

In 2020, Patani was among several Bollywood actors who were criticised for posting Instagram messages showing solidarity with the Black Lives Matter movement,

Patani completed shooting for Mohit Suri's Ek Villain Returns alongside Tara Sutaria, Arjun Kapoor and John Abraham

Disha went on to star in the commercially successful Hindi action films like Baaghi 2 (2018), Bharat (2019) and Malang (2020).

Disha Patani was born on 13 June 1993,[a] in Bareilly, Uttar Pradesh.[3][4] She is a Kumaoni,[5] from a Rajput background.